Drug Discovery, Development and Posology

Drugs are mainly formed by knowing active pharmaceutical ingredients (API) from traditional remedies or by serendipitous discovery.  But now we know diseases are controlled at molecular and physiological level. Also shape of a molecule at atomic level is well understood. Information of Human Genome is mainly studied during the drug development. Drug discovering methods include molecular manipulation and designing and also by knowing the drug metabolism. Here target selection, identification and validation is mainly done for drug discovery. The methods include target selection-lead discovery-medical chemistry-Invito studies –Invivo studies-clinical trials. Drug response will change its effect on individual caused by different levels of exposure former means dosage or amount of dose administered to a person, whereas the latter means the time-dependent concentration or concentration-derived parameters such as Area Under the Concentration curve and maximum level of concentration  of the drug after its administration.

 

  • Chronopharmacology and its effects
  • Study on physiology and biochemical response
  • Systemic biology & molecular pathology
  • Genomics and social aspects
  • Advancement using nanotechnology

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