Nurmeilis Nurdjaman Pujianto
Syarif Hidayatullah State Islamic University, Indonesia
Title: In-vivo anti-inflammatory activity of ethanol extract of the parijoto fruit (Medinilla speciosa Blume)
Biography
Biography: Nurmeilis Nurdjaman Pujianto
Abstract
Parijoto (Medinilla speciosa Blume) is traditionally plant that used on diarrheal diseases, inflammation and cancer sores and potentially as anti-hyperlipidemia and anti-bacterial that have been tested in vivo and in vitro. Based on research, parijoto fruit contains secondary metabolites such as flavonoids, tannins, saponins and glycosides. The purpose of this study was to determine the anti-inflammatory activity of the ethanol extract parijoto by using Carrageenan-Induced Paw Edema method. Sprague Dawley rats were divided into five groups: Negative control (Na CMC 0.5% b/v), positive control (Diclofenac sodium 5.14 mg/kg BW), ethanol extract parijoto fruit in various doses of 100, 200 and 400 mg/kg body weight. The test substances are given orally before induction with 0.2 mL carrageenan 1%. Measuring of the volume of rat's paw is conducted every hour for five hours after carrageenan induction by using plethysmometer. The results showed that rats which were given ethanol extract of 100, 200 and 400 mg/kg BW have significantly different percentage of edema compared to the negative control group (p≤0.05). The percentage of edema inhibitions within the subjects group with doses of 100, 200 and 400 mg/kg BW are 74.58%, 72.88%, dan 50.85%, respectively. This result suggested that extract ethanol parijoto fruits are able to inhibit edema of rat’s paw which is indicated that this extract has a potency to be developed as the anti-inflammatory agent.