Alaa Alqahtani
Umm Al- Qura University, Saudi Arabia
Title: Novel bufadienolide glycoside and a homoisoflavonoid from Rhodocodon campanulatus (Asparagaceae)
Biography
Biography: Alaa Alqahtani
Abstract
Rhodocodon campanulatus is a member of the bulbous Urgineeae tribe of the Scilloideae subfamily of the expanded Asparagaceae family (formerly Hyacinthaceae). Plants of the Urgineeae tribe are used as traditional remedies for the treatment of several ailments, such as infections, rheumatism, inflammation and disorders associated with the central nervous system. The Urgineeae tribe is distributed from South Africa to the Mediterranean, Saudi Arabia, India and Myanmar. The chemical constituents of plants of the Rhodocodon genus are not documented and hence the plant was investigated for chemo-taxonomical reasons. In this study we report the isolation of a novel bufadienolide glycoside and a known homo-isoflavonoid from the ethanol extract of the bulbs of Rhodocodon campanulatus. The major compounds were novel bufadienolide glycoside, 1, 3β-(O-β-D-glucopyranoside)- 14β-hydroxybufa-20,22-dienolid-19-al, and the known homo isoflavonoid, 2, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl) chroman-4-one, previously isolated from the South African Scilla kraussi. The structures of 1 and (2, 2a-b) (figure 1) were determined by the analysis of their NMR and MS spectra. The absolute configuration at C-3 for 2 was determined in this study as S on the basis of its electronic circular dichroism study. A positive Cotton effect at 290 was in agreement to those reported for homo isoflavonoid with H-3 in β position. Compound 1 was screened against NCI60 cancer cell lines and did not show any significant growth inhibition. Compound 2-2a-b was tested for anti-angiogenic inhibition ability. Compound 2b was found to be effective against the angiogenesis of human retinal micro vascular endothelial cells (HRECs) with GI50 values of 128 μM. Recent Publications 1. Schwikkard Sianne, Alqahtani Alaa, Knirsch Walter, Wertschnig Wolfgang, Jaksevicius Andrius, Opara Elizabeth, Langat Moses K and Mulholland Dulcie (2017) Phytochemical investigations of three Rhodocodon (Hyacinthaceae sensu APG II) species. J. Nat. Prod; 80: 30-37.